2nd to 4th digit ratios, fetal testosterone and estradiol. Lutchmaya S, Baron-Cohen S, Raggatt P, Knickmeyer RC, Manning JT. The ratio of 2nd to 4th digit length: A predictor of sperm numbers and concentrations of testosterone, luteinizing hormone and oestrogen. Manning JT, Scutt D, Wilson J, Lewis-Jones DI. Masculinized finger length patterns in human males and females with congenital adrenal hyperplasia. Taken together, the results of our study suggest research with larger samples is required to determine whether digit ratios are valid proxies for maternal sex hormone exposure.Ä«rown WM, Hines M, Fane BA, Breedlove SM. However, the first of these effects is in the opposite direction to that predicted by theory. Nevertheless, the multivariate level of analysis did reveal that T correlated positively with left hand digit ratio (L2D:4D) and negatively with D. Although the testosterone (T) to estradiol (E) ratio correlated negatively with right hand digit ratio (R2D:4D) and directional asymmetry (right-minus-left) in digit ratio (D ), neither effect remained statistically significant once demographic and obstetric covariates were controlled for. We report the first pre-registered study to investigate mothers' early pregnancy sex hormone concentrations in relation to their children's digit ratios measured at 18-22-month follow-up. The ratio of index to ring finger (2D:4D) has been hypothesised to indicate prenatal androgen exposure, yet evidence for its validity is lacking.
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